Minnesota is a vibrant hub for healthcare software companies driven by innovative solutions and cutting-edge technology. These companies operate in diverse areas including electronic health records, clinical productivity, quality reporting, and clinical research. As health sectors continue to digitize, these companies offer comprehensive, cloud-based solutions designed to improve care coordination and patient outcomes. From empowering providers with succinct tools to boosting procedural efficiency, Minnesota’s healthcare software industry is characterized by robust growth and transformation, striving to augment healthcare delivery.


Top 22 healthcare software companies in Minnesota

1. MatrixCare

  • Website: matrixcare.com
  • Headquarters: Bloomington, Minnesota, United States
  • Founded: 1982
  • Headcount: 501-1000
  • Latest funding type: Acquired
  • LinkedIn

MatrixCare offers an award-winning, Best in KLAS comprehensive EHR solution, designed by clinicians. Their cloud-based app is used by tens of thousands of home health organizations to improve patient care.


2. Provation

  • Website: provationmedical.com
  • Headquarters: Minneapolis, Minnesota, United States
  • Founded: 1994
  • Headcount: 201-500
  • Latest funding type: Acquired
  • LinkedIn

Provation Medical is a leading provider of healthcare software and SaaS solutions for clinical productivity, care coordination, quality reporting, and billing. They empower providers to deliver quality healthcare for all. Their comprehensive portfolio spans the entire patient encounter, from pre-procedure through post-procedure.


3. Mednet

  • Website: mednetsolutions.com
  • Headquarters: Minnetonka, Minnesota, United States
  • Founded: 2001
  • Headcount: 51-200
  • Latest funding type: Series Unknown
  • LinkedIn

Mednet Solutions is a technology company that provides comprehensive, cloud-based eClinical platforms for clinical research. With over 21 years of experience, they offer innovative solutions to pharmaceutical, medical device, biotechnology, and Contract Research Organizations (CROs) around the world. Their platform includes key native modules such as electronic data capture, randomization, trial supply management, adjudication, and electronic patient-reported outcomes.


4. Madelia Health

Madelia Health is a company offering healthcare solutions and services. They aim to provide innovative technologies and tools to improve patient care and streamline medical processes. With a focus on efficiency and quality, Madelia Health strives to support healthcare providers in delivering better outcomes.


5. PenRad Technologies, Inc.

  • Website: penrad.com
  • Headquarters: Buffalo, Minnesota, United States
  • Founded: 1995
  • Headcount: 51-200
  • Latest funding type: Acquired
  • LinkedIn

PenRad is a company that provides software solutions for Women's Imaging reporting and data tracking. Their products help facilities comply with MQSA standards, improve workflow efficiency, and enhance patient communication. PenRad offers a range of solutions including automated data input, digital patient forms, virtual patient check-in, and more.


6. Health Billing Systems, LLC

  • Website: healthbilling.net
  • Headquarters: Plymouth, Minnesota, United States
  • Founded: 1991
  • Headcount: 51-200
  • Latest funding type: Seed
  • LinkedIn

Healthbilling.net is a company that specializes in providing health billing systems. They offer services and solutions to healthcare providers for efficient and accurate billing processes.


7. Sorna Corporation

  • Website: sorna.com
  • Headquarters: Eagan, Minnesota, United States
  • Founded: 1999
  • Headcount: 11-50
  • LinkedIn

Sorna.com offers medical imaging solutions and data management systems. Their products include automated DICOM CD burners, video converters to DICOM, and compact video recorders integrated with Vertex Video. They provide secure data transmission using DICOM TLS, allowing patients and providers to upload images and documents directly to the Vertex inbox. Sorna.com helps improve patient care by streamlining the process of combining and sending medical data to healthcare professionals.


8. Dosentrx

Dosentrx is a healthcare technology company that provides an all-in-one medication and therapy management platform. Their platform delivers precision inpatient medication management in an outpatient setting, offering tools for therapy engagement, medication administration, adherence monitoring, and care team oversight. With Dosentrx, patients can actively participate in their own healthcare and experience better outcomes.


9. Imbio

  • Website: imbio.com
  • Headquarters: Minneapolis, Minnesota, United States
  • Founded: 2012
  • Headcount: 11-50
  • Latest funding type: Series A
  • LinkedIn

Imbio is an AI company that provides personalized medicine solutions for physicians, health systems, and patients. Their AI algorithms analyze standard medical imaging to capture and quantify diseases early, offer treatment insights, and measure treatment success.


10. Blueprint Solutions LLC

Blueprint Solutions is a software services company that focuses on providing leading hearing practice software. Their flagship product, Blueprint OMS, serves as a foundation for managing and growing hearing practices. They offer features such as audiology and medical report writing, insurance billing, marketing, financial tracking, and payment processing. With outstanding customer service and support, Blueprint Solutions ensures an ongoing relationship with patients to improve retention and re-sell opportunities.


11. Healthland

  • Website: healthland.com
  • Headquarters: Minneapolis, Minnesota, United States
  • Founded: 1980
  • Headcount: 51-200
  • Latest funding type: Acquired
  • LinkedIn

Healthland.com offers healthcare related software products and services for hospitals and other healthcare providers.


12. Vessel Partners

Vessel Partners is a digital health product development firm that specializes in developing healthcare software, collaborates with clinicians, and ensures HIPAA compliance.


13. Glencoe Regional Health

  • Website: grhsonline.org
  • Headquarters: Glencoe, Minnesota, United States
  • Founded: 1941
  • Headcount: 501-1000
  • LinkedIn

GRHSOnline.org is a company that offers a comprehensive range of services in the healthcare sector. They provide innovative solutions and expert guidance to healthcare organizations, enabling them to optimize their operations and deliver high-quality patient care.


14. IRCS, Inc

  • Website: ircsinc.com
  • Headquarters: Hibbing, Minnesota, United States
  • Founded: 1982
  • Headcount: 1-10
  • LinkedIn

IRC is a company that offers IT services and EHR software solutions. They specialize in providing support for electronic health record systems and provide various IT services.


15. AfterFiveMD

AfterFive is a mobile app that allows doctors to quickly communicate with their patients and other healthcare professionals, review medical information, and complete tasks without leaving the app.


16. Sansio

  • Website: sansio.com
  • Headquarters: Duluth, Minnesota, United States
  • Founded: 1997
  • Headcount: 51-200
  • Latest funding type: Acquired
  • LinkedIn

Sansio is a company that offers easy, customizable documentation with advanced reporting to improve patient care and service delivery.


17. Optimilabs

  • Website: optimilabs.com
  • Headquarters: Saint Paul, Minnesota, United States
  • Headcount: 1-10

OptimiLabs can help you stay ahead of it all. We are a specialized consulting, development, and implementation firm dedicated to making your technology faster, economical, and far more secure. Our creators and solution developers have been leading the edge of computer technology for the past 20 years. As pioneers in cloud deployment, data security, and AI, we are maximizing the performance of the defense industry, the medical industry, and leaders who require the highest level of security and optimization. Embrace the future, let's work together.


18. Coherent Solutions

Coherent Solutions is a software product development and consulting company that brings together global expertise, innovation, and creativity to solve customer business problems.


19. WR Medical Electronics Co.

  • Website: wrmed.com
  • Headquarters: Maplewood, Minnesota, United States
  • Founded: 1962
  • Headcount: 11-50
  • LinkedIn

WR Medical Electronics Co. is a leading provider of Autonomic and Peripheral testing solutions. They offer efficient and validated equipment and software that help physicians and patients find answers faster. With personalized installation, training, and ongoing support, they ensure smooth operation of Autonomic and Peripheral labs. They specialize in manufacturing high-quality and robust equipment to support healthcare professionals in delivering the best care to their patients.


20. MediMatrix

  • Website: medimatrix.com
  • Headquarters: Minneapolis, Minnesota, United States
  • Headcount: 11-50
  • Latest funding type: Acquired
  • LinkedIn

MediMatrix is a healthcare solutions company that offers a suite of products aimed at streamlining operations and improving patient care. They provide tools such as MediMatrix Portable Connect, MediMatrix Rad Connect, and MediMatrix Hospital Connect, which enable fast and accurate sharing of results with reading groups and electronic medical record systems. With integration services with PointClickCare, they cater to the needs of senior care providers in the LTPAC market.


21. Healthcare Academy (HCA)

Healthcare Academy is a learning management system provider in the healthcare industry. They offer a platform for authentication and session launch. Their SSO Gateway allows seamless access to their learning resources.


22. Billiyo Health Inc.

  • Website: billiyo.com
  • Headquarters: Minneapolis, Minnesota, United States
  • Founded: 2014
  • Headcount: 11-50
  • Latest funding type: Seed
  • LinkedIn

Billiyo is a technology-first platform for post-acute care providers in the home health care industry. It offers a comprehensive and affordable all-in-one software solution that integrates medical billing, business operations, clinical documentation, communication, and automation. The platform streamlines business management tools, reduces manual data verification, and enhances communication with staff, clients, families, and providers. With features like real-time messaging, EVV-enabled mobile capabilities, and a fully integrated document workflow, Billiyo empowers post-acute care providers to deliver better patient care and improve operational efficiency.


Want to find more healthcare software companies?


If you want to find more companies that offer cutting-edge solutions for improved patient care and clinical coordination you can do so with Inven. This list was built with Inven and there are hundreds of companies like these globally.


With Inven you'll also get to know the company's:


  • Ownership: Which of these are private equity backed? Which are family-owned?
  • Contact data: Who are the owners and CEO's? What are their emails and phone numbers?
  • Financials: How do these companies perform financially? What are their revenues and profit margins?

...and a lot more!