Colorado's biotechnology industry is a thriving center for innovation in health and science. It comprises companies that develop applications in biotechnology, targeted therapies, genomics, and proteomics, to name a few. These companies seek to improve patient care, detect and evaluate disease, facilitate informed treatment decisions, and propel precision medicine methodologies. The industry is geared towards advancing the humankind's health care system, with many companies focusing on the development of lifesaving, disease-targeting treatments. The future of this industry is headed towards merging scientific research with state-of-the-art technology to result in an enhanced understanding of the complexities of human health.


Top 21 biotechnology companies in Colorado

1. Clovis Oncology

  • Website: clovisoncology.com
  • Headquarters: Boulder, Colorado, United States
  • Founded: 2009
  • Headcount: 201-500
  • Latest funding type: Ipo
  • LinkedIn

Clovis Oncology is a company dedicated to improving the lives of people living with cancer by developing targeted therapies. They aim to realize the promise of precision medicine by ensuring the right drug gets to the right patient.


2. Biodesix, Inc.

  • Website: biodesix.com
  • Headquarters: Boulder, Colorado, United States
  • Founded: 2005
  • Headcount: 51-200
  • Latest funding type: Post Ipo Equity
  • LinkedIn

Biodesix is a clinical diagnostics company that offers personalized patient care and improves disease detection, evaluation, and treatment. They provide fast and reliable genomic and proteomic tests to gain a deeper understanding of each patient's disease state, expedite diagnosis, and guide confident treatment decisions.


3. ArcherDX, Inc.

  • Website: archerdx.com
  • Headquarters: Boulder, Colorado, United States
  • Founded: 2013
  • Headcount: 201-500
  • Latest funding type: Acquired
  • LinkedIn

ArcherDX, Inc., creates catalog and custom next-generation sequencing (NGS) assays that are purpose-built to identify mutations and gene fusions from clinical sample types. By combining novel enrichment chemistry, automated informatics and a user-friendly workflow, Archer® products remove the bottlenecks associated with using next-gen sequencing in a translational setting.


4. TriSalus Life Sciences

  • Website: trisaluslifesci.com
  • Headquarters: Westminster, Colorado, United States
  • Founded: 2009
  • Headcount: 51-200
  • Latest funding type: Series E
  • LinkedIn

TriSalus Life Sciences is a company focused on developing transformative treatments for liver and pancreatic tumors. They aim to address the barriers of immunosuppression and delivery through their integrated approach tailored to the target organ and disease biology. Their therapeutic platform is designed to be used in combination with systemic immunotherapies, with the potential to improve the lives of patients.


5. Enveda Biosciences

  • Website: envedabio.com
  • Headquarters: Boulder, Colorado, United States
  • Founded: 2019
  • Headcount: 51-200
  • Latest funding type: Series B
  • LinkedIn

Enveda Biosciences is a biotechnology company that integrates multiple data streams to identify potential therapeutic hypotheses, target candidates, and mechanisms of action. They leverage machine learning and AI-generated hypotheses to discover novel medicines within the plant realm. Enveda harnesses the power of nature's chemistry to develop next-gen small molecule therapeutics.


6. Flagship Biosciences, Inc.

  • Website: flagshipbio.com
  • Headquarters: Broomfield, Colorado, United States
  • Founded: 2009
  • Headcount: 51-200
  • Latest funding type: Series Unknown
  • LinkedIn

Flagship Biosciences is a laboratory software solutions provider that offers more accurate and informative tissue data and analytics. They provide pharma services and specialize in CDx development, clinical diagnostics, and data analysis. Their vision is to provide sophisticated spatial biology and biomarker analysis solutions to improve drug development and clinical diagnostics. They offer services to pharmaceutical companies, researchers, and medical professionals.


7. Concentric Ag

Concentric Agriculture is a company that utilizes proprietary microbial consortia technology to create beneficial bacteria and yeasts as soil and plant boosters. These products improve crop yields and replenish soils, while being economical for farmers and safe for the environment.


8. Crestone Pharma

  • Website: crestonepharma.com
  • Headquarters: Boulder, Colorado, United States
  • Founded: 2009
  • Headcount: 51-200
  • Latest funding type: Grant
  • LinkedIn

Crestone Inc. is a clinical stage biopharmaceutical company based in Boulder, Colorado, focused on developing novel mechanism of action small molecule drugs for serious bacterial infections. With a pipeline that includes treatments for C. difficile infection, MRSA, tuberculosis, and antibiotic-resistant Gram-positive infections, Crestone works to address significant unmet medical needs.


9. Infinome Biosciences

  • Website: infinomebio.com
  • Headquarters: Boulder, Colorado, United States
  • Headcount: 11-50
  • Latest funding type: Acquired
  • LinkedIn

Infinome Biosciences is a lean bioengineering company that specializes in unlocking the infinite potential of the genome. They offer high throughput phenotyping with smart automation, analytics, and informatics to rapidly characterize genetic variants and accurately predict scale-up performance. With their expertise in fermentation, automation, analytics, software & information systems, and directed evolution, they enable massive throughput biology and provide optimized microbial processes in a matter of weeks or months.


10. GlobeImmune, Inc.

  • Website: globeimmune.com
  • Headquarters: Louisville, Colorado, United States
  • Founded: 1995
  • Headcount: 11-50
  • Latest funding type: Ipo
  • LinkedIn

GlobeImmune is a biotechnology company that develops Tarmogens, a targeted molecular immunotherapy that activates the immune system by stimulating T cells to destroy infected or malignant cells. Unlike traditional vaccines, Tarmogens specifically target antigens associated with oncology indications and infectious diseases. GlobeImmune offers product candidates for the treatment of cancer and infectious diseases.


11. Reven Pharmaceuticals

  • Website: reven.com
  • Headquarters: Golden, Colorado, United States
  • Founded: 1999
  • Headcount: 11-50
  • Latest funding type: Series D
  • LinkedIn

Reven is a pharmaceutical company focused on developing a new generation of pharmacological solutions. They aim to target the root cause of diseases by restoring immune system homeostasis. With their proprietary process, they have created RJX, a drug that can effectively address various disease indications stemming from inflammation.


12. Theralink Technologies, Inc.

  • Website: theralink.com
  • Headquarters: Golden, Colorado, United States
  • Founded: 2005
  • Headcount: 11-50
  • Latest funding type: Post Ipo Equity
  • LinkedIn

Theralink Technologies, Inc. is a precision medicine company that utilizes Reverse Phase Protein Array (RPPA) technology to enable physicians to make personalized treatment recommendations for cancer patients. They offer the Theralink Assay, which evaluates protein biomarkers to guide cancer treatment decisions. Theralink also provides biopharma services to accelerate drug discovery programs.


13. Vitro Biopharma, Inc.

  • Website: vitrobiopharma.com
  • Headquarters: Golden, Colorado, United States
  • Founded: 1986
  • Headcount: 11-50
  • Latest funding type: Debt Financing
  • LinkedIn

Vitro Biopharma is a biologics company committed to translating science into medicines that transform the lives of patients with various diseases.


14. OnKure Therapeutics

OnKure Therapeutics is a biotechnology company dedicated to discovering and developing precision medicines in the field of oncology. They focus on developing innovative therapies for various types of cancer. With a broad pipeline of potentially best-in-class tumor-agnostic therapies, they aim to provide personalized treatments for patients with cancer.


15. ARCA biopharma, Inc.

ARCA biopharma is a pharmaceutical company that focuses on precision medicine and the development of potential treatments for cardiovascular diseases, particularly atrial fibrillation. They specialize in the research and development of Gencaro™, a unique beta-blocker and mild vasodilator. Their mission is to address the unmet medical needs in the treatment of atrial fibrillation and improve patient outcomes.


16. Ampio Pharmaceuticals, Inc.

  • Website: ampiopharma.com
  • Headquarters: Englewood, Colorado, United States
  • Founded: 2011
  • Headcount: 11-50
  • Latest funding type: Post Ipo Equity
  • LinkedIn

Ampio Pharmaceuticals is an innovative drug discovery and development company that combines scientific, clinical, and manufacturing capabilities. Their aim is to develop novel therapies for conditions with limited treatment options.


17. Bion

  • Website: biontech.com
  • Headquarters: Crestone, Colorado, United States
  • Founded: 1989
  • Headcount: 51-200
  • Latest funding type: Post Ipo Equity
  • LinkedIn

BioNTech is a biotechnology company that specializes in immunotherapies for cancer and infectious diseases. They use mRNA technology to develop a range of treatments that target unique cancer indications.


18. ProPharma Partners International

ProPharma Partners provides consulting services to biotechnology and pharmaceutical industries in North America, Europe and Japan. They specialize in product and technology in-licensing and out-licensing, preclinical and clinical management services, early stage financing strategies, due diligence assessments, and valuation determination.


19. Atlas Sports Genetics

  • Website: atlasgene.com
  • Headquarters: Boulder, Colorado, United States
  • Headcount: 11-50

Atlas Gene is a company that specializes in genetic research with a focus on providing gene therapy solutions to patients with genetic disorders.


20. Aytu BioPharma

  • Website: aytubio.com
  • Headquarters: Englewood, Colorado, United States
  • Founded: 2015
  • Headcount: 51-200
  • Latest funding type: Post Ipo Debt
  • LinkedIn

Aytu BioPharma is a healthcare company that focuses on improving children's health. They offer a portfolio of products, including innovative therapies for complex conditions and a line of fluoride and vitamin supplements for healthy growth. Additionally, they provide personal care and wellness products for the whole family.


21. Inscripta, Inc.

  • Website: inscripta.com
  • Headquarters: Boulder, Colorado, United States
  • Founded: 2015
  • Headcount: 51-200
  • Latest funding type: Series Unknown
  • LinkedIn

Inscripta is a company that combines biology and data science to bring affordable and sustainable synthetic biology products to market.


Want to find more biotechnology companies?


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