Top 23 Pioneers in Viral Vector Gene Therapy
Top 23 Pioneers in Viral Vector Gene Therapy
Operating within the biotech industry, Viral Vector Gene Therapy companies focus primarily on providing groundbreaking solutions to treat genetic disorders. These biotech firms utilize viral vectors, which are tools commonly used by molecular biologists to deliver genetic material into cells. This approach, in turn, renders possibilities for treating diseases related to genetic malfunctions. Much of their work contributes to ongoing research and therapeutic applications for severe diseases including, but not limited to, cancer and inherited disorders. The future of this industry holds promising prospects, with potential to revolutionize how we treat genetic diseases and enhance human health.
Top 23 Viral Vector Gene Therapy Companies
1. Spark Therapeutics, Inc.
- Website: sparktx.com
- Headquarters: Philadelphia, Pennsylvania, United States
- Founded: 2013
- Headcount: 501-1000
- Latest funding type: Acquired
Spark is a gene therapy company that strives to challenge the inevitability of genetic disease. They aim to discover, develop, and deliver potential treatments in ways unimaginable, combining their proprietary gene therapy platform with excellence in research and manufacturing.
2. Oxford Biomedica
- Website: oxb.com
- Headquarters: Oxford, Oxfordshire, United Kingdom
- Founded: 1995
- Headcount: 501-1000
- Latest funding type: Post Ipo Equity
Oxford Biomedica (oxb.com) is an innovative leading viral vector specialist - Lenti, AAV, Adeno and beyond - focused on delivering life changing therapies to patients. Their viral vector platform enables customers to bring next generation treatments for serious diseases to market.
3. CRISPR Therapeutics
- Website: crisprtx.com
- Headquarters: Cambridge, Massachusetts, United States
- Founded: 2013
- Headcount: 201-500
- Latest funding type: Grant
CRISPR Therapeutics is a company that specializes in gene editing and cell therapies. They use the CRISPR/Cas9 therapeutic approach to treat genetically-defined diseases by editing cells inside the body.
4. FinVector Oy
- Website: finvector.com
- Headquarters: Kuopio, Eastern Finland, Finland
- Founded: 2013
- Headcount: 201-500
FinVector is a company that offers services in viral-based product types, including Adenoviral, AAV, and Lentiviral-based vectors. They have a fully-licensed GMP manufacturing facility in Finland and provide gene therapy products and technologies to clients.
5. Center for Breakthrough Medicines
- Website: breakthroughmedicines.com
- Headquarters: King Of Prussia, Pennsylvania, United States
- Founded: 2020
- Headcount: 201-500
- Latest funding type: Corporate Round
Center for Breakthrough Medicines (CBM) is a cell and gene therapy contract development, manufacturing, and testing organization (CDMO). They are committed to saving lives by accelerating the development and manufacturing of advanced therapies. CBM offers fully integrated services for drug substance and drug product at a single site, including viral vector manufacturing, cell therapy manufacturing, plasmid DNA manufacturing, and analytical development & testing. They have a team of industry-leading professionals and are focused on providing high-quality, regulatory-compliant solutions.
6. Forge Biologics
- Website: forgebiologics.com
- Headquarters: Columbus, Ohio, United States
- Founded: 2020
- Headcount: 51-200
- Latest funding type: Series C
Forge Biologics is a company focused on developing innovative gene therapies to treat patients with devastating rare diseases. They offer end-to-end manufacturing services, from preclinical to commercial, to accelerate gene therapy programs. Their team of diverse and passionate individuals trailblazes a new model for making medicines. They specialize in AAV gene therapies and operate a state-of-the-art GMP facility called 'the Hearth.'
7. Andelyn Biosciences
- Website: andelynbio.com
- Headquarters: Columbus, Ohio, United States
- Founded: 2020
- Headcount: 201-500
- Latest funding type: Grant
Andelyn Biosciences is a biopharmaceutical manufacturing company that offers a broad range of viral vector and vaccine manufacturing services. They also specialize in manufacturing research and toxicology grade plasmids. With cGMP facilities and rigorous process development guidelines, they provide scalable and reliable solutions for their clients' manufacturing needs.
8. Genethon
- Website: genethon.fr
- Headquarters: Évry, Île-De-France, France
- Founded: 1990
- Headcount: 51-200
Genethon is a company dedicated to the development of gene therapy drugs for rare diseases. They focus on the preclinical and clinical development of gene therapy drugs for rare diseases. Genethon's pipeline includes therapies for various rare diseases such as Duchenne muscular dystrophy, spinal muscular atrophy, and Wiskott-Aldrich syndrome.
9. Krystal Biotech, Inc.
- Website: krystalbio.com
- Headquarters: Pittsburgh, Pennsylvania, United States
- Founded: 2015
- Headcount: 51-200
- Latest funding type: Post Ipo Equity
Krystal Biotech is a biotechnology company focused on developing and commercializing genetic medicines for patients with rare diseases. They have a wide-ranging pipeline based on their proprietary redosable HSV vector. The company is headquartered in Pittsburgh, Pennsylvania, and has core capabilities in viral vector design, vector optimization, gene therapy manufacturing, and commercialization.
10. PsiOxus
- Website: psioxus.com
- Headquarters: Abingdon, Oxfordshire, United Kingdom
- Founded: 2010
- Headcount: 51-200
PsiOxus Therapeutics is a clinical-stage company focused on redefining therapies for solid tumors with the potential to cure patients' cancer. They develop and deliver single or multi-protein therapeutics to tumors via an intravenously injected viral vector, reprogramming the tumor microenvironment and providing new treatment options for cancer patients.
11. Oxgene
- Website: oxgene.com
- Headquarters: Oxford, Oxfordshire, United Kingdom
- Founded: 2011
- Headcount: 51-200
- Latest funding type: Acquired
OXGENE is a company that specializes in cutting-edge science with a focus on gene therapy development. They offer innovative solutions and services to accelerate the discovery and biomanufacture of CAR-T / Cell Therapies and Gene Therapies, aiming to be the first to deliver breakthrough therapeutics to patients in need.
12. Dyno Therapeutics
- Website: dynotx.com
- Headquarters: Watertown, Massachusetts, United States
- Founded: 2018
- Headcount: 51-200
- Latest funding type: Series A
Dyno Therapeutics is a cutting-edge company focused on next-gen gene therapy vectors for muscle disease. They are recognized as one of the most promising startups of 2021, with significant partnerships and awards. Their innovative lab and talented team drive their search for transformative vectors. With a recent successful Series A financing led by Andreessen Horowitz, Dyno is poised for further growth and success.
13. Expression Therapeutics, Inc.
- Website: expressiontherapeutics.com
- Headquarters: Tucker, Georgia, United States
- Headcount: 11-50
Expression Therapeutics is a clinical stage gene and cell therapy company focused on developing potentially curative therapeutics for deadly childhood and adult genetic diseases. They utilize a multi-platform approach and proprietary non-signaling chimeric antigen receptor technology to enhance targeting capability and alleviate concerns of long-term T cell ablation and tonic signaling. Their clinical programs use lentiviral and adeno-associated viral vectors.
14. Capsigen
- Website: capsigen.com
- Headquarters: Vancouver, Washington, United States
- Founded: 2020
- Headcount: 11-50
- Latest funding type: Seed
Capsigen is a biotech company specializing in gene therapy. With their proprietary Transcription-Dependent Directed Evolution (TRADE™) technology, they develop high-quality viral vectors for gene therapy product development. Their platform enables efficient identification of fully functional capsids designed to meet complex disease-specific transduction profiles. Capsigen's powerful data science platform provides valuable insights into structure-function relationships, enhancing the potency of their viral vectors. They collaborate with partners to deliver fit-for-purpose vectors designed for tomorrow's medicine. Capsigen aims to push the boundaries of gene therapy and revolutionize the treatment of genetic disorders.
15. 64x Bio
- Website: 64xbio.com
- Headquarters: San Francisco, California, United States
- Founded: 2018
- Headcount: 11-50
- Latest funding type: Series A
64x Bio is a platform technology company that enables pharmaceutical and biotechnology companies to bring cell and gene therapies to patients more effectively. They provide purpose-built genetically engineered cell lines that increase viral vector production efficiency, improve manufacturing capacity, and reduce manufacturing cost.
16. CellVec Pte Ltd
- Website: cellvec.com
- Headquarters: Singapore, Central Region, Singapore
- Founded: 2018
- Headcount: 11-50
CellVec is a Cell and Gene Therapy Contract Development and Manufacturing Organization (CDMO) that specializes in the production of viral vectors for gene therapy and other cellular ATMPs. They utilize their lentivirus-based CellVec Vector Platform to overcome technological bottlenecks and develop novel gene transfer technologies, ultimately facilitating the advancement of their clients' products from bench-to-bedside for clinical applications.
17. GenomeFrontier Therapeutics, Inc.
- Website: genomefrontier.com
- Headquarters: Taipei City, T&S;Ai-Pei, Taiwan
- Headcount: 11-50
GenomeFrontier Therapeutics, Inc. is a biotechnology company that specializes in developing gene-modified cell therapies for the treatment of diseases, particularly cancer. They have integrated four platforms, namely Quantum Nufect, Quantum pBac, iCellar, and G-Tailor, to optimize vector delivery, therapeutic gene integration, cell expansion capacity, and gene design. Their Quantum Engine™ creates virus-free, gene-modified cells for cell modified gene therapy. They are focused on developing targeted immunotherapies, such as CAR-T and TCR-T therapies, which enhance the immune system's ability to fight cancer.
18. Cobra Biologics, A Charles River Company
- Website: cobrabio.com
- Headquarters: Keele, Stoke-On-Trent, United Kingdom
- Founded: 1992
- Headcount: 201-500
- Latest funding type: Grant
Cobra Biologics, a Charles River company, is a leading international contract development and manufacturing organisation (CDMO) providing biologics and pharmaceuticals for pre-clinical, clinical and commercial supply. The team at Cobra's GMP approved facilities has expertise tailored to serving customers around the world offering a broad range of integrated and stand-alone contract development and manufacturing services for clinical trials and the commercial market. As a trusted provider and a key partner in the drug development and commercialisation process, we take pride in our manufacturing excellence and comprehensive range of services to the pharmaceutical and biotech industries.
19. Touchlight
- Website: touchlight.com
- Headquarters: Hampton, Shropshire, United Kingdom
- Founded: 2008
- Headcount: 51-200
- Latest funding type: Grant
Touchlight is a biotechnology company that revolutionizes genetic medicine through its synthetic DNA vector, dbDNA™. With its enzymatic production, Touchlight provides rapid, scalable, and pure DNA necessary for the growth of genetic medicines.
20. Asimov
- Website: asimov.com
- Headquarters: Boston, Massachusetts, United States
- Founded: 2017
- Headcount: 11-50
- Latest funding type: Series B
Asimov is a synthetic biology company that specializes in the design and manufacture of advanced therapies through intelligent cellular circuit computing with DNA. They provide tools, software, cells, and genes for developing custom cell lines in-house, as well as commercial-grade cell line development services. Asimov collaborates with various companies, from biotechs to big pharma, and offers a platform for designing and optimizing genetic systems. They also offer host cells, grant software access, and support for therapeutic applications.
21. Ring Therapeutics
- Website: ringtx.com
- Headquarters: Cambridge, Massachusetts, United States
- Founded: 2017
- Headcount: 11-50
- Latest funding type: Series B
Ring Therapeutics is a biotech company revolutionizing medicine with commensal viruses. Using their Anellogy™ platform, they harness the power of the human commensal virome to develop diverse therapeutic modalities. Their novel approach aims to safely and effectively deliver therapies to target cells and tissues.
22. Life Edit Therapeutics
- Website: lifeeditinc.com
- Headquarters: Research Triangle Park, North Carolina, United States
- Founded: 2017
- Headcount: 11-50
- Latest funding type: Acquired
Life Edit Inc. is a company that specializes in gene editing therapies for patients with genetic diseases. They are dedicated to making innovative and curative treatments accessible to those in need. With a focus on discovery and unlimited potential, they aim to rewrite the future of gene editing by providing versatile options for targeting genetic disorders.
23. Flash Therapeutics
- Website: flashtherapeutics.com
- Headquarters: Toulouse, Occitanie, France
- Founded: 2018
- Headcount: 11-50
- Latest funding type: Debt Financing
Flash Therapeutics is a company that specializes in providing purified and highly concentrated particles for gene therapy. With their expertise in lentiviral vector manufacturing, they support projects from research to GMP grade production. They offer R&D and GMP manufacturing services and have partnered programs in regenerative medicine and cell therapy.
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