The biopharmaceutical industry is a thriving sector that focuses on the development and manufacturing of biological medicinal products. Companies in this field primarily produce drugs derived from living organisms, often geared towards rare and difficult-to-treat diseases. Pennsylvania, known for its cutting-edge technological capabilities and forward-thinking approach, has emerged as a significant hub for these bio ventures. Companies like CSL Behring and Frontage Laboratories are iconic examples of Pennsylvania's robust biopharmaceutical landscape, offering products and services ranging from treatments for rare diseases to clinical trial management.


Top 25 biopharmaceutical companies in Pennsylvania

1. CSL Behring

  • Website: cslbehring.com
  • Headquarters: King Of Prussia, Pennsylvania, United States
  • Founded: 1904
  • Headcount: 10001+
  • LinkedIn

CSL Behring is a global biotech company that manufactures and sells products to treat rare diseases. They are driven by the promise to save lives and protect the health of people.


2. Frontage Laboratories, Inc

  • Website: frontagelab.com
  • Headquarters: Exton, Pennsylvania, United States
  • Founded: 2001
  • Headcount: 501-1000
  • Latest funding type: Ipo
  • LinkedIn

Frontage Lab is a full service CRO that specializes in biomarker discovery and formulation development. They offer comprehensive laboratory testing, clinical trials management, and drug development services. With over 20 years of experience, they have completed more than 20 studies in Phase I-IIa. Frontage Lab provides services in clinical services, exome sequencing, genetic toxicology, mass spectrometry, and medicinal chemistry.


3. Amicus Therapeutics

  • Website: amicusrx.com
  • Headquarters: Philadelphia, Pennsylvania, United States
  • Founded: 2002
  • Headcount: 501-1000
  • Latest funding type: Post Ipo Debt
  • LinkedIn

Amicus Therapeutics is a biotechnology company at the forefront of advanced therapies for rare genetic diseases. They develop innovative treatments and leverage technology platforms to improve the lives of patients. Their pipeline includes programs for Fabry Disease, Pompe Disease, Batten Disease, and other rare diseases. They offer products like Galafold® and Amicus Assist™.


4. Abec

  • Website: abec.com
  • Headquarters: Bethlehem, Pennsylvania, United States
  • Founded: 1974
  • Headcount: 501-1000
  • Latest funding type: Seed
  • LinkedIn

ABEC is a bioprocess engineering and consulting company that provides customized solutions and services for biotech manufacturing. They offer process engineering, equipment, single-use solutions, and support for the development and manufacturing of biopharmaceutical products.


5. WuXi Advanced Therapies

Advanced Therapies is a cell and gene therapy development and manufacturing organization (CTDMO) based in Philadelphia, PA. They provide integrated contract testing, development, and manufacturing services for clinical and commercial cell and gene therapies. Their expertise includes viral clearance validation, analytical development, cell line characterization, and materials characterization.


6. Arbutus Biopharma Corporation

  • Website: arbutusbio.com
  • Headquarters: Warminster, Pennsylvania, United States
  • Founded: 1992
  • Headcount: 51-200
  • Latest funding type: Post Ipo Equity
  • LinkedIn

Arbutus Biopharma Corporation (NASDAQ:ABUS) is a clinical-stage biopharmaceutical company leveraging its extensive virology expertise to develop novel therapeutics that target specific viral diseases, mainly chronic hepatitis B virus (cHBV) and coronaviruses (including COVID-19). They are developing RNAi therapeutics, oral PD-L1 inhibitors, and oral RNA destabilizers to provide a functional cure for chronic HBV patients and pursue combination therapies for COVID-19 and future coronavirus outbreaks.


7. Venatorx Pharmaceuticals, Inc.

  • Website: venatorx.com
  • Headquarters: Malvern, Pennsylvania, United States
  • Founded: 2010
  • Headcount: 51-200
  • Latest funding type: Series Unknown
  • LinkedIn

Venatorx Pharmaceuticals is a private company focused on the discovery and development of novel anti-infectives to treat multi-drug-resistant (MDR) bacterial infections and hard-to-treat viral infections.


8. Madrigal Pharmaceuticals

  • Website: madrigalpharma.com
  • Headquarters: Conshohocken, Pennsylvania, United States
  • Founded: 2016
  • Headcount: 51-200
  • Latest funding type: Post Ipo Equity
  • LinkedIn

Madrigal Pharma is a company that offers innovative pharmaceutical solutions. With a focus on research and development, they strive to create cutting-edge drugs to address unmet medical needs.


9. MOBILion Systems, Inc.

  • Website: mobilionsystems.com
  • Headquarters: Chadds Ford, Pennsylvania, United States
  • Founded: 2015
  • Headcount: 51-200
  • Latest funding type: Series C
  • LinkedIn

MOBILion Systems is a company that develops high-resolution and throughput analytical instruments for pharmaceutical and clinical researchers. Their technology, SLIM (Structures for Lossless Ion Manipulation), allows for the identification of clinically significant molecules and biomarker discovery. Their products provide unprecedented sensitivity, resolution, and throughput, enabling the development of more effective therapeutics and diagnostic assays.


10. PhaseBio Pharmaceuticals, Inc.

  • Website: phasebio.com
  • Headquarters: Malvern, Pennsylvania, United States
  • Founded: 2002
  • Headcount: 11-50
  • Latest funding type: Post Ipo Equity
  • LinkedIn

PhaseBio Pharmaceuticals is a company dedicated to developing specialized and innovative therapies for cardiovascular diseases. With a focus on high-quality science, they aim to provide superior outcomes for patients and the healthcare system.


11. Aro Biotherapeutics

  • Website: arobiotx.com
  • Headquarters: Philadelphia, Pennsylvania, United States
  • Founded: 2018
  • Headcount: 11-50
  • Latest funding type: Series B
  • LinkedIn

Aro Biotherapeutics is a biotechnology company that specializes in the development of tissue-targeted genetic medicines using their proprietary protein technology called Centyrins. They are focused on creating a new class of receptor-targeted genetic medicines to modulate gene targets in disease tissues.


12. BriaCell Therapeutics Corp.

  • Website: briacell.com
  • Headquarters: Philadelphia, Pennsylvania, United States
  • Founded: 2004
  • Headcount: 11-50
  • Latest funding type: Post Ipo Equity
  • LinkedIn

BriaCell Therapeutics Corp. is a clinical-stage immunotherapy company focused on developing treatments for breast cancer. Their lead candidate, Bria-IMT™, is an immunotherapy approach that stimulates the body's own cancer-fighting cells to attack and destroy breast cancer tumors. They also have Bria-OTS™, an off-the-shelf personalized immunotherapy based on a patient's HLA-type. BriaCell is currently evaluating the safety and efficacy of Bria-IMT™ in combination with Incyte's immunotherapies. They have a strong management team and a clinical strategy team with experience in drug approvals.


13. Immunome, Inc.

  • Website: immunome.com
  • Headquarters: Exton, Pennsylvania, United States
  • Founded: 2008
  • Headcount: 11-50
  • Latest funding type: Grant
  • LinkedIn

Immunome is a biotech company specializing in the discovery and development of antibody-based therapeutics for areas of high unmet medical need, including cancer and infectious diseases.


14. Noveome Biotherapeutics, Inc.

  • Website: noveome.com
  • Headquarters: Pittsburgh, Pennsylvania, United States
  • Founded: 2000
  • Headcount: 11-50
  • Latest funding type: Series Unknown
  • LinkedIn

Noveome Biotherapeutics, Inc. is a biotech company specializing in the development of innovative biologics for a variety of medical conditions. They offer a portfolio of products targeting important ophthalmic indications. With a focus on scalable manufacturing, Noveome aims to provide cutting-edge treatments to patients in need.


15. ArriVent Biopharma

  • Website: arrivent.com
  • Headquarters: Pennsylvania Furnace, Pennsylvania, United States
  • Founded: 2021
  • Headcount: 11-50
  • Latest funding type: Series B
  • LinkedIn

ArriVent Biopharma is a pharmaceutical company that focuses on developing transformative medicines for cancer patients. They source scientifically validated discoveries globally and forge strategic collaborations to maximize therapeutic and market potential. Their goal is to provide patients worldwide with new treatment options.


16. Peptilogics

  • Website: peptilogics.com
  • Headquarters: Pittsburgh, Pennsylvania, United States
  • Founded: 2013
  • Headcount: 11-50
  • Latest funding type: Grant
  • LinkedIn

Peptilogics is revolutionizing the discovery process for novel peptide therapeutics for patients with serious and life-threatening diseases. They combine the untapped potential of peptide biology with the power of machine learning, creating the next generation of medicines through precision engineering and design.


17. Nexstone Immunology

Nexstone Immunology is a Blackstone Life Sciences portfolio company advancing its lead drug candidate in the field of immunology and inflammation. With a focus on addressing unmet treatment needs in immune-mediated diseases, Nexstone combines therapeutic expertise with advanced drug development.


18. Idera Pharmaceuticals

  • Website: iderapharma.com
  • Headquarters: Exton, Pennsylvania, United States
  • Founded: 1989
  • Headcount: 11-50
  • Latest funding type: Post Ipo Equity
  • LinkedIn

Idera Pharmaceuticals is a company focused on developing novel therapies for patients with rare diseases, particularly in the fields of pulmonology and rheumatology. They aim to improve outcomes for patients who currently have limited or no available treatment options.


19. XyloCor Therapeutics, Inc.

  • Website: xylocor.com
  • Headquarters: Wayne, Pennsylvania, United States
  • Founded: 2013
  • Headcount: 11-50
  • Latest funding type: Series A
  • LinkedIn

XyloCor Therapeutics is a company dedicated to improving the lives of people with cardiovascular disease through the advancement of gene therapy. They develop proprietary products that address significant unmet clinical needs in cardiovascular disease.


20. Talee Bio

  • Website: taleebio.com
  • Headquarters: Philadelphia, Pennsylvania, United States
  • Founded: 2016
  • Headcount: 11-50
  • Latest funding type: Grant
  • LinkedIn

Spirovant Sciences is a bio-pharmaceutical company that specializes in developing gene therapy treatments for respiratory diseases.


21. Novasenta

  • Website: novasenta.com
  • Headquarters: Pittsburgh, Pennsylvania, United States
  • Founded: 2018
  • Headcount: 11-50
  • Latest funding type: Series A
  • LinkedIn

Novasenta is a leading scientific company that focuses on disease and immunity, providing innovative solutions and services to help combat diseases.


22. Drug Discovery Online

Drug Discovery Online provides information and resources to the biopharmaceutical research community to accelerate drug discovery and development.


23. Eurofins Central Laboratory

Eurofins Central Laboratory is a global company offering comprehensive and high-quality clinical laboratory testing solutions. With operations in the US, Europe, India, Singapore, and China, we provide a wide range of services to support vaccine development, biopharma services, specialty testing, biomarker services, and more.


24. Biosimilar Development

Biosimilar Development provides content and resources for companies and professionals involved in the development, manufacturing, testing, and commercialization of biosimilars and biologics.


25. Jacobs Management Group, Inc.

  • Website: jacobsmgt.com
  • Headquarters: Philadelphia, Pennsylvania, United States
  • Founded: 1988
  • Headcount: 11-50
  • LinkedIn

Jacobs Management Group is a specialized recruitment firm that provides top industry talent for the medical device, pharmaceutical, biotech, and diagnostics industries. With over 30 years of experience, their expert search consultants connect clients with highly specialized positions ranging from executives to individual contributors.


Want to find more biopharmaceutical companies?


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